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i3 Membrane is your companion for life science filtration solutions and separation technologies. We work with and for our customers to develop high quality products in our Medical, Lab/Pharma and Biotech business units.
i3 Membrane shows that high tech can be small, compact and powerful. Caring for neonates and people who are immunocompromised or immunosuppressed is a task bearing a high level of responsibility. Protection from nosocomial infections is an important part of medical care. Sterile filtration belongs to this prevention strategy. The more compact and efficient sterile filters are, the less they interfere with central working procedures. For this area of use, i3 Membrane has developed a compact high-performance point-of-use sterile filter that forms a barrier against waterborne microbes.
Contamination of solid materials, and also of liquid and gaseous media, presents laboratory professionals with more and more difficult tasks. A basic requirement in the manufacture of pharmaceuticals and chemical agents, for example, is that the product be free from nanoparticles and microstructures. Constant monitoring is therefore essential.
Ultrathin layers of gold, titanium and other precious metals on high quality polymer membranes make it possible for the surfaces of i3's membranes to be electrically conductive. These layers provide optimal reflection in Fourier transform infrared (FTIR) microscopy and Raman spectroscopy and form a suitable conductive substrate for imaging with scanning electron microscopy (EDX/WDX). The standardized membranes are used in asbestos analysis, sample preparation (for HPLC and other methods) and particle analysis of solid and liquid materials for the pharmaceutical, chemical and automobile industries.
For individual areas of application, we produce specially coated track-etched from different polymer compounds. These filters have different pore sizes, diameters and coating thicknesses. To stabilize the membranes during the filtration phase, the gold-coated filters can be supplied mounted in aluminum rings. Aluminum oxide membranes are used for rapid filtration with simultaneous efficient separation to achieve maximum purity.
The manufacture of monoclonal antibodies is the most dynamic area in the biopharmaceutical industry. Their use in research and development, diagnostic procedures and therapeutic applications requires complex, multi-stage purification processes with separation columns that are capital-intensive and offer limited options for changes of scale. For some time, an alternative to separation columns has been gaining ground in the form of chromatographic membranes. These are equipped with defined positively or negatively charged binding sites. Compared to separation columns they can achieve higher flow rates and an effective transfer of mass. Biomolecules that have been adsorbed onto these binding sites can be recovered only by means of larger changes in pH value or high salt concentrations in the rinsing fluid. Desorption does not differ from separation column chromatography in this respect.
Digital membrane chromatography opens up a new dimension in separation technology. The chemical binding properties of the stationary phase can be switched over by control of the electrical potential so that biomolecules can be separated with high selectivity. This means that both adsorption and desorption occur as a result of simple potential regulation. Unlike conventional membrane chromatography, the purification of antibodies and the concentration of endotoxins can thus be achieved without large-scale use of buffer solutions or increases in salt concentration. Digital membrane chromatography demonstrates binding capacities that are comparable to those of conventional membrane chromatography.
When developing new types of membrane and highly selective separation techniques, i3 Membrane cooperates with various research institutes such as
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